![]() ![]() In approximately 1/3 of ASD patients, the regression of language is observed between 18-24 months of age with the appearance of autistic behavior. Many authors have not reached a definite conclusion and there is no consensus on the neuropathophysiology of ASD. It is unclear if this suspicion is just an epiphenomenon of an underlying neural dysfunction in ASD or there is any causal relationship between ASD and epilepsy. This could also be supported by the reports of high rates of epilepsy or epileptiform electrocencephalography (EEG) in children with autism, and vice versa, as well as much higher prevalence of autism in children with epilepsy who also have learning problems. The fact that the epilepsy rate is much higher in ASD patients suggests that ASD and epilepsy might share a common pathophysiological basis. In general population, epilepsy is reported in only 0.5-1%. Epilepsy is reported to occur in one third of ASD patients but the exact prevalence is unknown with the literature reporting a wide range of estimates from 5 2) to 46% 3). ASD is believed to be related with central nervous system (CNS) dysfunction, and epilepsy is strongly associated. Autism spectrum disorders (ASD) are neurological and developmental disorders characterized by impairment of social relatedness, communication skills, restriction of interests and stereotyped behaviors 1). ![]()
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